Day 1 :
Keynote Forum
Lawrence Cyril Vitug
MD, MPM, Quirino Memorial Medical Center (QMMC), Quezon City, NCR Philippines
Keynote: Pregnancy in the Lungs: A Case Report of a Latent Metastatic Giant Choriocarcinoma of the Lung
Biography:
Lawrence Cyril G. Vitug, MD, MPM is an Internal Medicine resident in Quirino Memorial Medical Center at the time of publication the article. He had a Masteral degree in Public Management major in Health Systems and Development at the Development Academy of the Philippines, Degree in Doctor of Medicine, and Bachelor of Science in Nursing. Whose prior to Internal Medicine training, works as a Doctor to the Barrio assigned in geographically isolated nad disadvantaged areas in the Philippines. His experience in remote medicine, made hime realize his calling to specialize in Internal Medicine.
Abstract:
Gestational trophoblastic disease (GTD) is a spectrum of tumors that involve abnormal growth of cells commonly occurs in women of reproductive age. Choriocarcinoma a part of its spectrum, is a malignant form of GTD wherein it is more likely to grow quickly and metastasize to organs distant from the uterus. It is most great important to report these cases not only due to limitation of data but also as this presents a diagnostic and management dilemma. We describe an unusual chronology and presentation of clinical features and diagnostics that led to the diagnosis of a choriocarcinoma in the lungs of a 20 year old female in the Philippines. It is peculiar for a choriocarcinoma to grow into the lungs from a 4 year latency of a previous gestational event now presenting as a giant mass, with no evidence of any primary tumor. Pulmonary choriocarcinoma should be part of differential diagnosis of a young patient with a pleural effusion in a reproductive age. A multi-disciplinary approach is vital in patient’s presenting with pleural effusion with high index of suspicion of a GTD. Given a prolonged latency, metastatic choriocarcinoma originating from a previous molar pregnancy can be overlooked. The author finds the necessity to reclassify the current FIGO prognostication factor, giving more prognostic points in favor of choriocarcinoma presenting as giant or wherein an organ was entirely converted to a mass. It is also important to determine if the presenting choriocarcinoma in the lungs as either primary or metastatic, which presents as a dilemma in this case. It is imperative to give importance in the early diagnosis leading to early treatment of choriocarcinoma. For an Internist, great vigilance should be made in the follow-up for the detection of chorionic malignancy
- LUNGS 2022
Location: Dubai, UAE
Session Introduction
Joanna Wieczfinska
Department of Immunopathology, Medical University of Lodz, Poland
Title: Rhinovirus-induced airway remodeling is modulated by curcumin and is NF–κB dependent
Biography:
Joanna Wieczfinka has completed his PhD at the age of 28 years from Medical University of Lodz, Poland. She is a member of many international societies, connected with immunology, asthma, and other lung disease. She has published 23 papers in reputed journals and has been serving as a reviewer in many journals.
Abstract:
The aim of the present study was to evaluate the effect of curcumin on expression of the genes involved in the remodeling process in the context Rhinovirus infection. To achieve this, two lines of fibroblasts (WI-38 and HFL1) were treated with rhinovirus 2 and 16 and curcumin, and expression of the genes involved in remodeling process (MMP-9, TGF-β, CHI3L and ADAM33) was evaluated by qPCR and Western Blot. Moreover, NF –κB were silenced utilizing siRNABoth rhinoviruses induced expression of the genes evaluated: HRV16 caused stronger effect than HRV2, respectively: RQ for MMP-9=13 vs.12, TGF-β=7.6 vs. 7.2, CHI3L=3.4 vs. 3.2, ADAM33=4.8 vs. 4.6 (p<0.05). Curcumin significantly decreased MMP-9 and TGF-β expression (RQ=0.55 and 0.6 respectively, p<0.05). Importantly, curcumin significantly decreased Rhinovirus-induced expression of MMP-9 and TGF-β (RQ=8 for both HRV16 and HRV2, and RQ=5.3 for HRV16 and 5.1 for HRV2, respectively, p<0.05).
NF–κB siRNA revealed plays important role in remodeling-associated genes and curcumin action – the expression of each gene was lower when NF –κB was silenced (p<0.05).